Inhalation System

State-of-Art Solutions for In-Vivo & In-Vitro Inhalation Studies

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Precision Inhalation Systems for Diverse Applications

Drawing on over 40 years of experience, we are a leading manufacturer of in-vivo and in-vitro inhalation systems renowned for their precision and reliability. Our commitment extends beyond core systems by providing the scientific community with the widest range of substance delivery and analysis modules. This modularity empowers researchers to customize studies and address a broad spectrum of research needs.

German Engineering for Exceptional Performance: Our systems uphold precision engineering principles, ensuring exquisite accuracy and consistent data generation. This translates to robust and reliable research outcomes in diverse areas, including pharmacology, toxicology, environmental safety assessment and occupational health studies.

Expert Guidance for Compliant Studies: We recognize that successful inhalation studies require a holistic approach. Beyond equipment, we offer dedicated scientific consultations to ensure your study design meets regulatory guidelines, such as OECD, EPA, and GLP.

Selection of Available Modules

Exposure units

  • Cell Cultures
  • Head-Nose Towers
  • Whole Body Chambers
  • Large Animals Exposure Units

Analysis equipment

  • Concentration Measuring Unit.
  • Cascade Impactor
  • Particle Size Distribution
  • Nanoparticle Size Distribution

Environmental Control

  • Pressure Sensors
  • Temperature Sensor
  • Oxygen and Carbon Dioxide Sensors
  • Humidity Sensor

Test Substances

  • Liquid Aerosol
  • Dust Aerosol
  • Vapor
  • Nanoparticles

Animal species

  • Rodents
  • Dogs
  • Monkeys
  • Non-Human Primates

Essentials

  • Safety Cabinets and Hoods
  • Humidity Control System
  • 3-stage Exhaust air Filtration
  • Alarm Module

Head-Nose Exposure Towers

Modular Configuration: We offer a range of Head-Nose exposure towers specifically designed for inhalation studies in rodents and large laboratory animals, like dogs or non-human primates. These towers feature a modular design, allowing researchers to configure the system for studies involving 8 to 96 animals simultaneously. Large animal towers offer adaptability, allowing exposure and real-time individual concentration analysis for up to 4 animals at a time.

Flow-Through Design: The towers employ a sophisticated flow-pass design that guarantees uniform distribution of test substances throughout the exposure unit and avoiding an exhaled air rebreathing. This ensures consistent exposure across all animals within the system, minimizing confounding variables and enhancing data quality.

Environmental Monitoring: Beyond exposure control, our towers offer the option to integrate environmental sensors for real-time monitoring of critical parameters. These sensors measure temperature, humidity, oxygen (O2) and carbon dioxide (CO2) levels, and pressure. This monitoring plays a vital role in maintaining experiment integrity and optimizing animal welfare.

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Our System Modular and Extendable Architecture.

Together we are working on system configuration to meet study design requirements, safety assessment protocols and methodologies for measuring the properties of the tested substances.

Head-nose tower
Enables from 8 to 96 animals’ simultaneous exposure. For a wide range of species – mice to guinea pig size as standard, also available for large animals – dogs or non-human primates.
Liquid Aerosol generator
With a special nozzle for various liquids, including high-viscosity substances.
Dust Generator acc. to Budiman
Has a robust design for working with finely powdered and dry substances. The powder can be pressed into a small tablet or cake for the minimum amount used during the exposure.
Nebulizer
Suitable for loss-free nebulization from a liquid reservoir and together with Aerosol Drying Unit can be used for NanoParticle Generation
Dosing Unit
For providing liquid test substances.
Filter Analysis
A gravimetric determination of particle concentration via weight of the substance collected.
Temperature and Humidity sensor
for environment monitoring. Required according to OECD guidelines.
Pressure sensor for exposure unit
also available in a chemical-resistant version.
Pressure sensor for filter condition monitoring
also available in a chemical-resistant version.
Mass-Flow Controller
for clean dry air inflow.
Mass-Flow Controller
for compressed application air.
Mass-Flow Controller
for compressed air humidity generator.
Mass-Flow Controller
for automated air sampling.
Mass-Flow Controller
for exhaust air out.
Humidity Control Unit
required for extra dry substances.
Spectrometer
for real-time particle size and distribution analysis.
Process Control Unit
for real time concentration measurement
Sample pump
Three-stages filter station
each filter comes in a stainless-steel housing.
System Control unit with DACO Software
also available in GLP version.
Particle filter and Activated Carbon/HEPA filters
for the sample line devices and sensors protection
Real-Time Concentration Monitoring
Cascade Impactor for offline particle size distribution analysis
required according to OECD guidelines and comes with a dedicated software.
Exhaust Pump
CO2/O2 Measuring Unit

Benefits

Standard or Customized Modular Systems

Various Species from Rodents to Large animals

German Precision Engineering

Complete Automation and Control

Software and Documentation for GLP Validation

Validation Documentation including IQ, OQ

Whole Body Exposure Chambers

TSE Systems offers a range of whole-body exposure chambers specifically designed to deliver exceptional precision and reliability for in-vivo inhalation studies across various durations.

Optimized Airflow for Uniform Exposure: These chambers incorporate a thoroughly designed airflow system that guarantees equitable distribution of test substances throughout the chamber volume. This minimizes spatial gradients and ensures consistent exposure for all animals within the system, enhancing data quality and reducing variability.

Scalable Solutions for Diverse Needs: Available in standard sizes (0.05, 0.6, and 1 m3) with the option for customization, our chambers cater to a broad spectrum of research protocols. They are well-suited suitable for acute, sub-chronic studies and chronic studies.

Concentration Stability: Advanced engineering principles and integrated environmental monitoring systems work together to maintain stable exposure concentrations throughout the duration of the experiment. This unwavering consistency is paramount for ensuring the integrity and reproducibility of research data.

Enabling Reliable Inhalation Studies.

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Trusted by:

NEW Table Top System

Introducing new Head-Nose exposure unit that fits size requests and budget constraints. Its modular design meets diverse experimental needs. The compact system seamlessly integrates within existing fume hoods, facilitating efficient exhaust management and exposure control. This capability is particularly valuable for studies utilizing volatile or hazardous test substances.

Our Table Top system’s modularity extends to its scalable capacity, accommodating studies with 8 to 26 rodents. This flexibility allows researchers to tailor the exposure environment to the specific requirements of their investigation. Additionally, the lower internal volume minimizes the amount of test substance required for effective exposure, promoting cost-efficiency during studies. Modular design ensures a streamlined and time-saving setup process, allowing researchers to initiate studies more efficiently.

Streamline preclinical inhalation studies with modular design, high-precision exposure, and efficient substance utilization.

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Support

Safety operation features and tools for setting alarm and automatic shutdown.

Chemically resistant parts for aggressive substances

Integration of external equipment for substance generation and analysis

Training and Scientific Support including application training.

Comprehensive Calibration: we offer calibration kits to maintain accuracy and reliability in substance delivery.

Preventive maintenance 24/7 Service Hotline – round the clock for you

Publications

Andriamasinoro, S. N., Serventi, A. M., Veillette, R., Dieme, D., Haddad, S., & Bouchard, M. (2023).

Basil, M. C., Cardenas-Diaz, F. L., Kathiriya, J. J., Morley, M. P., Carl, J., Brumwell, A. N., Katzen, J., Slovik, K. J., Babu, A., Zhou, S., Kremp, M. M., McCauley, K. B., Li, S., Planer, J. D., Hussain, S. S., Liu, X., Windmueller, R., Ying, Y., Stewart, K. M., … Morrisey, E. E. (2022).

Kuntic, M., Kuntic, I., Krishnankutty, R., Gericke, A., Oelze, M., Junglas, T., Bayo Jimenez, M. T., Stamm, P., Nandudu, M., Hahad, O., Keppeler, K., Daub, S., Vujacic-Mirski, K., Rajlic, S., Strohm, L., Ubbens, H., Tang, Q., Jiang, S., Ruan, Y., … Münzel, T. (2023).

Xiong, K., Yang, P., Wei, W., Li, J., Cui, Y., Li, Y., & Tang, B. (2023).

Yi, J., Chen, B. T., Schwegler-Berry, D., Frazer, D., Castranova, V., McBride, C., Knuckles, T. L., Stapleton, P. A., Minarchick, V. C., & Nurkiewicz, T. R. (2013).

Center of Knowledge

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Inhalation blog post

scientists used a custom-built Inhalation system for mice from TSE Systems to investigate the combined exposure of mice to aircraft noise and airborne particulate matter (APM)

New study reveals tremendous impact of air pollution and traffic noise on health in mice.

Air pollution is a global environmental crisis that has been linked to an estimated 9 million premature deaths per year, according to The Lancet Commission…

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