Freely Moving Group-Housed Animal Stimulation & Monitoring
NeuroLux – the first commercially available platform allowing wireless optogenetic stimulation and physiological monitoring of central and peripheral nervous system as well as specific organs. This flexible and price-affordable solution offers, on a unique platform, a vast variety of methodologies ranging from optogenetic stimulation, drug delivery, real-time physiological monitoring and photometry, all in freely moving animals to maximize data reliability and reproductivity.
The NeuroLux Starter Kit is an all-inclusive package of all hardware, controller, as well as software to upgrade this technology quickly and easily in your existing experimental platform or housing cage. It allows up to 8 additional cages to be run simultaneously to increase experimental throughput. Master module powers and communicates other modules.
Wireless technology allows the investigation of freely moving animals
Battery-free system
Ultra-light design suitable for numerous animal models (mice, rats, birds, fishes…)
Vast variety of implant configurations for optogenetic and physiological monitoring of CNS and PNS for real-time control and data acquisition
Fully retro-compatible implants
Easy integration into home cage and experimental platforms and third-party system via TTL inputs
All devices for optogenetic stimulation can be freely configured with different stimulation wavelengths (μLED of 470/ 530/ 590/ 630 nm) and probe lengths (2, 4, 6 mm) depending on our targeted region/organ and opsins.
Stimulation device for Unilateral or Bilateral brain optogenetic stimulation in group housed condition.
Stimulation device for Bilateral brain optogenetic stimulation in group housed condition.
Devices specifically designed for spinal cord or small animal model stimulation (i.e., zebrafish).
A programable device allowing to perform individual-specific optogenetic stimulation patterns in group house conditions.
The transcranial device uses high-intensity light bursts to penetrate through the skull of a rodent offering a less invasive optogenetic modulation.
The first wireless device allows genetically encoded and virally expressed physiological monitoring protein system.
Fully-implantable for streaming body temperature and 3-axis acceleration data in freely moving rodents. Custom algorithms enable heart and respiration rate assessment and locomotor activity.
Back-mounted device capable of targeting peripheral regions across the animal’s body.
This device allows optogenetic stimulation or drug photoconversion experiments in parallel of electrical pacing of cardiac tissue
Due to past technical limitations, numerous scientific approaches required isolated animal housing. This limited natural social behaviors and animal well-being and necessitated frequent human intervention and animal handling, potentially impacting data reliability and reproducibility.
NeuroLux breaks these barriers and allow you to perform various and complementary research approaches directly within IntelliCage, a state-of-the-art automated system for assessing cognitive and behavioral function in up to 16 group-housed mice.
This powerful combination offers a multitude of benefits:
Neurolux, paired with IntelliCage, empowers you to conduct groundbreaking research in a natural and ethical setting.
Ouyang, W et al.; (2023). A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals. Nature Biomedical Engineering, 1–18.
Ausra, J et al.; (2021). Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds. Nature Communications, 12(1), 1968.
Grajales-Reyes, J. G et al.; (2021). Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice. Nature Protocols, 16(6), 3072–3088.
Yang, Y et al.; (2021). Wireless multilateral devices for optogenetic studies of individual and social behaviors. Nature Neuroscience, 24(7), 1035–1045.
Ausra, J et al.;. (2021). Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals. Proceedings of the National Academy of Sciences, 118(30), e2025775118. https://doi.org/10.1073/pnas.2025775118
Burton, A et al.; (2020). Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. Proceedings of the National Academy of Sciences, 117(6), 2835–2845. https://doi.org/10.1073/pnas.19200731172
Zhang, Y et al.; (2019). Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics. Proceedings of the National Academy of Sciences, 116(43), 21427–21437. https://doi.org/10.1073/pnas.1909850116
Zhang, Y et al.;. (2019). Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Science Advances, 5(7), eaaw5296. https://doi.org/10.1126/sciadv.aaw5296
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