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TSE MotoRater System
- Quantitative and objective evaluation of locomotor functions in rats and mice using high-speed video tracking
- Standardized modular system allows high flexibility of testing rodents during walking, wading and swimming
- Biomechanical assessments of all body parts at the same time
- High efficiency and throughput
The TSE MotoRater represents a novel and standardized set-up for quantitative and objective evaluation of locomotor functions of
the whole animal, not restricted to foot prints like other classic gate analysis systems. The unique modular design of the TSE MotoRater
allows to investigate the kinematics of rats and mice during skilled walking on a ladder or beam, overground walking, wading and swimming.
Objective, sensitive and specific readouts of locomotor impairments, recovery or improvement can be obtained. Moreover, movements of all
relevant body parts, i.e. forelimbs, hindlimbs, trunk and tail can be assessed at the same time, leading to a complete profile of the
animal's motor abilities. As a consequence, the TSE MotoRater is an improvement in the standardization of behavioral assessment of rodent
locomoter skills by replacing traditional scoring methods.
An arrangement of mirrors allows the recording of animals from the left and right side and from below at the same time. A color-based
tracking software allows automatic tracking of an unrestricted number of markers, such as knee, toe, hip or iliac crest and other skin
overlying anatomical landmarks. Therefore, a variety of behaviorally meaningful parameters can be obtained and are accomplished by detailed
biomechanical measurements.
RotaRod Advanced
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- Standard versions for 5 mice or 4 rats/mice simultaneously
- Speed range: 1-60 rpm, constant or accelerating/decelerating
- Programmable speed profiles with up to 100 individual steps for refined motor skill testing
- Including reverse rotation feature for maximum flexibility / additional dimensions for investigation
- Individual timers for measuring the times spent on the drum
- Animal falls are detected by light-beam sensors that are unnoticed by the animals
- Optional escape prevention cover set and electric shocker module
- Extra-high units available if shock reinforcement is not suitable
- Optional drawers to facilitate animal removal and cleaning
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The TSE RotaRod Advanced System is a flexible tool for studying motor coordination or fatigue resistance in rats and mice.
The apparatus basically consists of a rotating drum whose surface is designed to provide grip. Separating panels divide
the drum into individual lanes. We provide standard models for 5 mice and for 4 rats. The rat unit can also be upgraded
with a drum suitable for mice. For obese and/or old rats a model for 3 rats is available.
Motor speed for drum rotation is controlled electronically. Each RotaRod Advanced is supplied complete with a control unit
& PC interface. A user-friendly Windows softwareallows you to define, store and run automatically speed profiles with
up to 100 steps per profile. Within each step the initial speed, final speed as well as time for linear
acceleration/deceleration can be defined according to your choice / requirements. All RotaRod Advanced units are also
equipped with a programmable reverse rotation mode. Stored results data is easily transferred to Excel. With its most
flexible test protocols (uniqueon the market), performance differences between animals can be detected that cannot be
differentiated by other systems.
Each lane is controlled by its own timer which is operated independently. Animal falls are detected by light-beam sensors
mounted into each lane. Optional floor grids can be equipped with an electric shocker module to optionally apply an
electric reinforcement stimulus of variable length and intensity after falling.
Grip Strength Meter
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- Test of muscular strength in small laboratory animals
- Available as a stand-alone or PC-based sensor system
- Select between different maximum sensor capacities
- Height-adjustable sensor module
- Measure forelimb and hindlimb strength
- Standard or customized grip
- Optional PC connection
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The TSE Grip Strength Meter is a measuring system for determining the gripping strength of a small
laboratory animal (rat, mouse). Within the context of neuromuscular investigations this test system
can be used to quantify the effects of hormones, toxins, muscle relaxants as well as disease or the
aging process on the muscular strength of the animal.
In the trial setup the animal pulls a special height-adjustable grip which is mounted on a high-precision
force sensor. The standard sensor for mice allows measurement of up to 600 ponds; that for rats up to 2000
ponds. If the animal releases the grip the force exerted is shown on the digital display of a
connected control unit. In addition, the analog waveform can be shown on a chart recorder.
For maximum convenience the setup can be connected to a PC. The TSE Grip Strength Meter software for Windows
allows easy data acquisition. If the animal releases the grip the value is shown on the computer
monitor and is simultaneously stored in a format that can be easily imported into Excel for further
statistical calculations.
Running Wheel Systems Passive
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- Measures spontaneous activity in a home cage
- Suited for long-term circadian studies
- Made from stainless steel or MRI-compatible plastics
- "Enabled / Disabled" feature controls wheel availability depending on time and/or animal activity
- Computer-controlled rotation resistance for work load control
- Optional exchange wheel drums with variable rod spacing for automated motor skill testing
- Optional positive or negative reinforcement
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The TSE family of Running Wheels is used to measure voluntary (spontaneous) activity of the animal in a home cage. The
wheel drum is fixed to a base with integrated rotary sensor that detects movement with 90° resolution in both
directions. A cage-specific separating panel prevents the rotary sensor from becoming soiled by litter. An optional lid
is available to close the wheel if it is intended to be operated outside the home cage.
Wheels for voluntary running are available with a stand-alone counter or as computer-controlled systems. In
computer-controlled versions the wheels can be equipped with a software-adjustable rotation resistance module for
applying different work loads to study motivation or endurance. Wheel running availability can be modified with the
brand-new "Enabled/Disabled" function – selectable criteria are time-control and/or distance run. In combination with our
new automated behavioral PhenoMaster platform this feature can also be useful as a new measure of reinforcement in operant
studies.
All automated wheel systems are integrated into the powerful TSE PhenoMaster /
LabMaster platform and can therefore be used as part of a multi-dimensional metabolism & behavior testing
platform.
Running Wheel Systems Active
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- Exercise wheels for forced wheel running for mice & rats
- Mouse wheel: diameter 115mm, drum width 40mm
- Rat wheel: diameter 250mm, drum width 80mm
- Stand-alone wheels with manual motor control and digital speed readout
- Computer-controlled systems with software-controlled speed profiles for maximum flexibility
- Computer-controlled wheels allow the definition of user-defined exercise protocols
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TSE Active Wheels are equipped with a motor for forced wheel activity. This can be useful in the context of sleep
deprivation studies or in studies of controlled exercise. These running wheels are usually operated outside the home
cage and are provided with a removable waste pan underneath. The stainless steel rods have species-specific
dimensions. The wheel can be easily removed from the motor base unit for cleaning purposes.
TSE Active Wheels are available as stand-alone units or as computer-controlled systems. In the economical stand-alone
configuration the wheel is connected to a motor control that allows the stepless adjustment of the motor speed to
control the exercise intensity. The current speed can be read from a digital display. The computer-controlled systems
are provided with a Windows software that allows the free definition of speed profiles for advanced exercise
protocols.
In the CaloWheel configuration these wheels allow the performance of calorimetric exercise tests with the
calorimetry module of the TSE
PhenoMaster / LabMaster platform.
CaloWheel – Calorimetric Exercise Wheel
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- Combines forced activity wheel running with open-circuit indirect calorimetry
- Airtight acrylic housing with reduced volume for optimum calorimetric results plus maximum visibility
- Automatic recording and analyzing of metabolic parameters: VO2, VCO2, Respiratory
Exchange Rate (RER), Energy Expenditure (EE)
- Proven gas sensor technique
- Species-specific motor with manually adjustable speed
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The CaloWheel system is an automated running wheel for rats or mice suitable for measurements of metabolic parameters
during physical activity ("exercise calorimetry"). The wheel is coupled to a motor with adjustable speed control –
the selected speed is displayed on a digital readout. For cleaning purposes the wheel can be easily removed from the
motor drive.
The sealed housing has separate air inlet, air outlet and sample air connections and is coupled to a fully
computer-controlled TSE calorimetry setup. The calorimetry module of the
TSE PhenoMaster / LabMaster platform features a user-friendly software that
controls the experimental procedure and collects the measuring data. Measurement of O2 consumption and
CO2 production during exercise allows the automatic calculation of a number of calorimetric parameters such
as energy expenditure and respiratory exchange rate. Data is presented graphically and numerically and is available as
an export file for statistical evaluation.
Treadmill Systems Advanced
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- Up to 8 individual exercise lanes for high throughput measurement for mice or rats
- Angle of inclination adjustable between -10 and + 25 degrees
- Software-programmable speed profiles
- Trial start is registered for each lane individually by its own timer
- Adjustable light-beam sensors for each lane detect when the animal leaves the running belt
- Pre-programmed foot shock can be applied when the animal leaves the belt
- Optional TTL high signal output with each change of speed
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The TSE Treadmill Advanced System is a fully computerized electronically-controlled system suitable for the study
of exercise physiology in rats and mice. The Treadmill is driven by a servo-controlled motor which provides precise
operator-defined speed profiles. The user-friendly Windows software allows you to program, store and run
user-defined speed profiles as a combination of constant speed and acceleration/deceleration phases with adjustable
durations. The available speed range is 0.07- 2m/sec depending on the species. Test modes allow the application of
electric stimuli by manual control. The generated data files are compatible with all common spreadsheet programs for
further statistical evaluation.
The Treadmill Advanced system is also available in a calorimetric configuration (CaloTreadmill) if metabolic
parameters are to be measured in parallel by indirect calorimetry with the
calorimetry module of the TSE
PhenoMaster / LabMaster platform.
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